Etoposide breast

The combination of irinotecan and etoposide showed modest efficacy in terms of response rate in the refractory setting for patients with metastatic breast cancer. As single agents, both irinotecan and etoposide have documented activity against breast cancer among patients who have received multiple lines of prior chemotherapy. Irinotecan interacts with topoisomerase I Topo I to stabilize its cleavable complex, and etoposide has an analogous interaction with topoisomerase II Topo II. This stabilization without rapid resealing of the cleavage point results in apoptotic cell death and accounts for the antitumor activity of these agents. Topo II levels may increase after administration of a Topo I inhibitor, thus providing a rationale for combining these agents in practice.
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Oral etoposide in heavily pre-treated metastatic breast cancer: A retrospective series.

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A Phase II Study of Irinotecan and Etoposide as Treatment for Refractory Metastatic Breast Cancer

Colleague's E-mail is Invalid. Your message has been successfully sent to your colleague. Save my selection. No standard chemotherapy has been defined for metastatic breast cancer MBC patients pretreated with anthracyclines and taxanes. A multicenter phase 2 study was conducted to evaluate the safety and efficacy of oral etoposide in patients with MBC.
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A Phase II Study of Irinotecan and Etoposide as Treatment for Refractory Metastatic Breast Cancer

Study record managers: refer to the Data Element Definitions if submitting registration or results information. This study will examine how the body handles etoposide, a drug used to treat breast cancer. The knowledge gained may lead to more effective use of the drug with fewer side effects in the future. Breast cancer patients who are receiving etoposide as part of their treatment may participate in this study. Patients will have 18 blood samples about a teaspoon or less each drawn over a hour period during and after their infusion of etoposide.
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