Bone scan imaging breast cancer metasis

Skeletal metastases cause significant morbidity, including pain, fractures, hypercalcemia, and spinal cord compression; patients in whom disease is confined to the skeleton have the greatest risk of skeleton-related events 5. The median survival of patients with disease confined to the skeleton is relatively long compared with that of patients with visceral disease 2. With the arrival of effective novel therapies, it has become even more important to detect bone metastases at an early stage to minimize skeleton-related events and to allow the determination of a response as early as possible to limit toxicity and accelerate the therapeutic transition in nonresponding patients. At the same time, there has been an increase in the use of other hybrid techniques for imaging of the skeleton e. Despite improved accuracy in staging of the skeleton, evidence of efficacy and consensus regarding effective monitoring of a treatment response are lacking.

Risk of metastasis among rib abnormalities on bone scans in breast cancer patients

Imaging Bone Metastases in Breast Cancer: Staging and Response Assessment.

Breast cancer Abstract Bone scan abnormalities, especially rib lesions, are often confusing for physicians due to a high number of false-positive lesions. This study investigated risk factors that are associated with bone metastasis in breast cancer patients with bone scan abnormalities. Significantly increased rates of bone metastasis were observed in patients with multiple lesions, large tumor sizes and lymph node involvement. In the subset of patients with rib abnormalities, the rate of metastasis was extremely low in patients with pure rib lesions 1. Our data suggest that patients with pure rib abnormalities could be recommended for follow-up only.

Imaging Bone Metastases in Breast Cancer: Staging and Response Assessment.

Corresponding author. Received Jun 4; Accepted Aug This article has been cited by other articles in PMC.
The need for informed consent was waived. Bone scintigraphy protocol Whole-body bone scintigraphy was performed 4 hours after the injection MBq of Tcm methylene diphosphonate. Anterior and posterior views were acquired using a dual-headed gamma camera equipped with low-energy, high-resolution collimator Varicam, GE Healthcare, Milwaukee, WI.
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